Sleep: DNA Repair Function for Better Neuronal Aging?
نویسندگان
چکیده
منابع مشابه
Changes in DNA repair during aging
DNA is a precious molecule. It encodes vital information about cellular content and function. There are only two copies of each chromosome in the cell, and once the sequence is lost no replacement is possible. The irreplaceable nature of the DNA sets it apart from other cellular molecules, and makes it a critical target for age-related deterioration. To prevent DNA damage cells have evolved ela...
متن کاملDNA Repair, Genome Stability, and Aging
Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging. We review Sir2, a factor linking genomic stability...
متن کاملChromatin Remodeling, DNA Damage Repair and Aging
Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all DNA-related events. Studies on human premature aging...
متن کاملDNA Repair, Human Diseases and Aging
One of the most fundamental functions of a cell is the transmission of genetic information to the next generation, with high fidelity. On the face of it, this seems a challenging task given that cells in the human body are constantly exposed to thousands of DNA lesions every day both from endogenous and exogenous sources. Yet, for long periods of time, the DNA sequences are one of the most inva...
متن کاملDNA damage and repair in telomeres: relation to aging.
We have established a method for the detection of DNA damage and its repair in human telomeres, the natural ends of chromosomes which are necessary for replication and critical for chromosomal stability. We find that ultraviolet light-induced pyrimidine dimers in telomeric DNA are repaired less efficiently than endogenous genes but more efficiently than inactive, noncoding regions. We have also...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2019
ISSN: 0960-9822
DOI: 10.1016/j.cub.2019.05.018